目(mu)前在中(zhong)藥(yao)(yao)領域，國外或國內大多數從事超臨界萃(cui)取(qu)設備的(de)(de)(de)技術研究(jiu)(jiu)開(kai)發應(ying)用(yong)雖(sui)有(you)報道，但(dan)缺(que)乏系統性，大多只停留在中(zhong)藥(yao)(yao)有(you)效成分或中(zhong)間(jian)原料(liao)提取(qu)方(fang)面(mian)，這僅(jin)僅(jin)是用(yong)于(yu)(yu)中(zhong)藥(yao)(yao)的(de)(de)(de)一個方(fang)面(mian)。中(zhong)藥(yao)(yao)的(de)(de)(de)研究(jiu)(jiu)與開(kai)發具(ju)有(you)特殊(shu)性，即必須(xu)具(ju)有(you)藥(yao)(yao)理臨床(chuang)效果，因此，超臨界萃(cui)取(qu)技術用(yong)于(yu)(yu)中(zhong)藥(yao)(yao)必須(xu)結合(he)藥(yao)(yao)理臨床(chuang)研究(jiu)(jiu)，只有(you)工(gong)藝上優越，藥(yao)(yao)理臨床(chuang)效果又(you)保(bao)證或更(geng)好，超臨界萃(cui)取(qu)技術在該領域的(de)(de)(de)生(sheng)命力(li)或潛力(li)才能真(zhen)正體現。
目前(qian) SFE主(zhu)要用在天(tian)然(ran)藥(yao)(yao)(yao)物中(zhong)有效(xiao)成分(fen)的(de)萃取，而且多用于單個藥(yao)(yao)(yao)物中(zhong)純天(tian)然(ran)成分(fen)提取．我們認為對我國應(ying)用歷 史悠久的(de)古方(fang)中(zhong)一些中(zhong)成藥(yao)(yao)(yao)復方(fang)制劑，以及許多中(zhong)藥(yao)(yao)(yao)中(zhong)具很強藥(yao)(yao)(yao)理活性，參與(yu)生命功能活動的(de)多糖成分(fen)．也應(ying)該進(jin)行采用SFE提取工藝(yi)的(de)研究與(yu)新(xin)藥(yao)(yao)(yao)開發，這也是使中(zhong)藥(yao)(yao)(yao)與(yu)國際接軌(gui)，實(shi)現中(zhong)藥(yao)(yao)(yao)現代化的(de)必經之路(lu)。
中(zhong)藥(yao)(yao)(yao)生(sheng)產(chan)現代化(hua)(hua)和(he)(he)質(zhi)量(liang)標(biao)準科學化(hua)(hua)是(shi)發(fa)展(zhan)中(zhong)藥(yao)(yao)(yao)，走向世界的關鍵(jian)．在(zai)中(zhong)藥(yao)(yao)(yao)研制(zhi)和(he)(he)開發(fa)中(zhong)，必(bi)須逆循“三效(xiao)(xiao)(xiao)“(速(su)效(xiao)(xiao)(xiao)、高(gao)效(xiao)(xiao)(xiao)、長效(xiao)(xiao)(xiao))，"三小"(劑(ji)量(liang)小、副作(zuo)用(yong)(yong)(yong)小、毒性(xing)(xing)(xing)小)，"五方(fang)便"(生(sheng)產(chan)、運輸、儲藏、攜帶、使(shi)(shi)用(yong)(yong)(yong)方(fang)便)為(wei)目(mu)的之(zhi)原則．為(wei)此(ci)(ci)，必(bi)須選用(yong)(yong)(yong)一(yi)些現代高(gao)新工藝(yi)技術．近(jin)年(nian)發(fa)展(zhan)的SFE技術用(yong)(yong)(yong)于(yu)提(ti)取(qu)天然(ran)藥(yao)(yao)(yao)物中(zhong)的有效(xiao)(xiao)(xiao)成(cheng)(cheng)分，特(te)別適合對濕(shi)熱不穩定的物質(zhi)，又無(wu)殘(can)留溶(rong)(rong)劑(ji)、無(wu)回收(shou)溶(rong)(rong)劑(ji)造成(cheng)(cheng)環境污染(ran)的缺陷，而且提(ti)取(qu)速(su)度(du)快、可(ke)(ke)(ke)縮短生(sheng)產(chan)周(zhou)期。無(wu)疑是(shi)既可(ke)(ke)(ke)提(ti)高(gao)收(shou)率及產(chan)品純度(du)、又可(ke)(ke)(ke)降低成(cheng)(cheng)本的一(yi)種(zhong)高(gao)新技術可(ke)(ke)(ke)推廣(guang)使(shi)(shi)用(yong)(yong)(yong)．但是(shi)因為(wei)本法采取(qu)的萃(cui)取(qu)劑(ji)均為(wei)脂溶(rong)(rong)性(xing)(xing)(xing)，所以(yi)對極性(xing)(xing)(xing)偏大或分子量(liang)偏大(一(yi)般(ban)大于(yu)500時)的有效(xiao)(xiao)(xiao)成(cheng)(cheng)分提(ti)取(qu)收(shou)率較差，今后必(bi)須在(zai)選用(yong)(yong)(yong)合適夾(jia)帶劑(ji)加入方(fang)面下功夫．當然(ran)，國(guo)外已(yi)有報道應(ying)用(yong)(yong)(yong)全(quan)氟聚醚碳酸銨可(ke)(ke)(ke)使(shi)(shi)SFE法擴展(zhan)到水溶(rong)(rong)性(xing)(xing)(xing)體系，使(shi)(shi)難(nan)以(yi)提(ti)取(qu)的強極性(xing)(xing)(xing)化(hua)(hua)合物如蛋白等(deng)成(cheng)(cheng)分由(you)SFE法萃(cui)取(qu)．近(jin)年(nian)來SFE技術又與色(se)譜(pu)、質(zhi)譜(pu)、高(gao)壓液相色(se)譜(pu)等(deng)高(gao)新分析(xi)儀器(qi)聯用(yong)(yong)(yong)，成(cheng)(cheng)為(wei)一(yi)種(zhong)有效(xiao)(xiao)(xiao)的分離、分析(xi)手段，能(neng)高(gao)效(xiao)(xiao)(xiao)、快速(su)地(di)進行藥(yao)(yao)(yao)物成(cheng)(cheng)分的分析(xi)。使(shi)(shi)一(yi)些中(zhong)藥(yao)(yao)(yao)制(zhi)劑(ji)能(neng)借此(ci)(ci)制(zhi)訂(ding)出能(neng)指(zhi)導生(sheng)產(chan)操作(zuo)和(he)(he)反映產(chan)品內在(zai)質(zhi)量(liang)均一(yi)性(xing)(xing)(xing)、有效(xiao)(xiao)(xiao)性(xing)(xing)(xing)、穩定性(xing)(xing)(xing)、重現性(xing)(xing)(xing)的可(ke)(ke)(ke)控指(zhi)標(biao)，實施質(zhi)量(liang)標(biao)推科學化(hua)(hua)。
開原化工(gong)機械制造有(you)限公(gong)(gong)司的(de)主要產(chan)品有(you)三大板(ban)塊：第一是超臨界流(liu)體設(she)備(bei)，是國內較(jiao)早生產(chan)超臨界流(liu)體設(she)備(bei)的(de)專業(ye)廠家。該類設(she)備(bei)屬于快開門式(shi)高壓(ya)(ya)(ya)(ya)容(rong)器(qi)，目前我公(gong)(gong)司單臺(tai)容(rong)積最(zui)(zui)大已做到(dao)(dao)5000L，最(zui)(zui)高壓(ya)(ya)(ya)(ya)力達到(dao)(dao)52MPa，最(zui)(zui)大直徑達到(dao)(dao)2500mm。此類容(rong)器(qi)還可(ke)應用于模擬深(shen)海的(de)外壓(ya)(ya)(ya)(ya)試驗、襯四(si)氟泵(beng)閥及管件的(de)等(deng)壓(ya)(ya)(ya)(ya)加(jia)壓(ya)(ya)(ya)(ya)等(deng)場(chang)合。第二是多晶硅(gui)還原爐(lu)(lu)，多晶硅(gui)還原爐(lu)(lu)是用于生產(chan)多晶硅(gui)的(de)核心設(she)備(bei)。第三是高壓(ya)(ya)(ya)(ya)反應釜，是我公(gong)(gong)司的(de)傳統產(chan)品。同時，我公(gong)(gong)司還有(you)高壓(ya)(ya)(ya)(ya)儲(chu)罐、高壓(ya)(ya)(ya)(ya)換(huan)熱(re)器(qi)和低溫設(she)備(bei)產(chan)品等(deng)。
